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A2-typed kidneys labeled A1 by serology were transplanted safely

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Research area:medicine-clinicalclinical-methods

What the study found

The study found that kidneys from donors labeled as blood group A1 by serology, but confirmed as A2 by genotyping, were transplanted safely into ABO O and B recipients. The authors report favorable outcomes and no graft losses attributed to ABO incompatibility.

Why the authors say this matters

The authors conclude that using ABO genotyping, a genetic test that identifies blood group more precisely than serologic testing, could expand the donor pool for disadvantaged candidates. They also suggest this approach may reduce wait times by making more kidneys available for transplantation.

What the researchers tested

The researchers studied kidney transplants from donors labeled A1 by serology but genotyped as A2. Genotyping was done with real-time PCR or next-generation sequencing, and the team analyzed biopsy-proven rejection, anti-HLA and anti-ABO antibodies, and allograft loss.

What worked and what didn't

In this cohort, allograft survival was 100%. No graft losses were attributed to ABO incompatibility, and the abstract does not report graft losses from this cause.

What to keep in mind

The abstract does not provide detailed sample size, follow-up length, or comparative data against other donor-recipient groups. It also does not describe limitations beyond the available summary.

Key points

  • Kidneys labeled A1 by serology but confirmed as A2 by genotyping were transplanted to ABO O and B recipients.
  • The cohort had 100% allograft survival.
  • No graft losses were attributed to ABO incompatibility.
  • Genotyping was performed using real-time PCR or next-generation sequencing.
  • The authors support ABO genotyping as a routine supplement to serologic testing.

Disclosure

Research title:
A2-typed kidneys labeled A1 by serology were transplanted safely
Authors:
Nassir M Thalji, Matthias Kapturczak, Tamer Shaker, Ranjeeta Chand, William J. Lane, Cathi Murphey
Institutions:
Brigham and Women's Hospital, Harvard University, Houston Methodist, Houston Methodist, Houston Methodist, Houston Methodist, Immunodiagnostic Systems (Denmark), Methodist Healthcare, Methodist Healthcare, Methodist Healthcare, Methodist Healthcare
Publication date:
2026-07-01
DOI:
10.1016/j.humimm.2026.111743
OpenAlex record:
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AI provenance: This post was generated by gpt-5.4-mini (OpenAI). The original authors did not write or review this post.

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