What the study found
The review argues that brain health and resilience are important for shaping trajectories of late-life neuropsychiatric and neurodegenerative disorders. It describes brain health as a dynamic balance of neural, cognitive, and emotional processes that supports resilience to neuropsychiatric illness.
Why the authors say this matters
The authors say understanding and promoting brain health is becoming a priority for preventing neuropsychiatric disorders across the lifespan. They conclude that integrating neurobiological, psychological, behavioral, and sociocultural domains may help inform next-generation strategies in neuropsychopharmacology, prevention science, and healthy brain aging.
What the researchers tested
This is a review article, not a new experimental study. The authors synthesize evidence on the determinants of brain health in aging and bring together findings from neuroscience, lifestyle medicine, geroscience, and social determinants of health.
What worked and what didn't
The review highlights resilience as a modifiable pathway linking neuropsychiatric illness risk and prevention. It also discusses emerging frameworks such as brain clocks, precision biomarkers, digital phenotyping, and artificial intelligence as tools for risk stratification, early detection, and personalized intervention.
What to keep in mind
The abstract does not report new data, effect sizes, or direct comparisons. Specific limitations of the review are not described in the available summary.
Key points
- The review presents brain health as a balance of neural, cognitive, and emotional processes.
- Resilience is described as a modifiable pathway related to neuropsychiatric illness risk and prevention.
- The authors emphasize a whole-person, life-course approach to aging and brain health.
- The review discusses brain clocks, precision biomarkers, digital phenotyping, and AI as possible tools for earlier detection and personalized intervention.
- No new experimental results or numerical findings are reported in the abstract.
Disclosure
- Research title:
- Review links brain health and resilience to healthy aging
- Authors:
- Helen Lavretsky, Sahib S. Khalsa, Hanadi Ajam Oughli, Agustin Ibanez, Josefina Cruzat, Emmeline Edwards, Paul Newhouse, Claudio L. A. Bassetti, Indrit Bègue, Andrea Sylvia Winkler, Dilip V. Jeste, Harris Eyre
- Institutions:
- Adolfo Ibáñez University, Adolfo Ibáñez University, Geneva College, Health Net, National Center for Complementary and Integrative Health, Neurobehavioral Systems, Rice University, Technical University of Munich, Trinity College Dublin, University Hospital of Bern, University Hospital of Geneva, University of California, Los Angeles, University of California, Los Angeles, University of Oslo, Vanderbilt University Medical Center
- Publication date:
- 2026-01-28
- OpenAlex record:
- View
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