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Cardiac biomarkers rise with hypertensive disorders in pregnancy

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Research area:medicine-clinicalclinical-methods

What the study found

Pregnant women with hypertensive disorders had higher levels of several cardiac and tissue injury biomarkers than normotensive pregnant women, and the increases were greatest in preeclampsia. The strongest rise was seen in NT-proBNP, a biomarker of ventricular wall stress.

Why the authors say this matters

The authors conclude that these biomarkers may help with risk assessment and clinical monitoring in hypertensive disorders of pregnancy. They also state that integrating specific biomarkers into routine screening could support earlier risk stratification and improve maternal-foetal outcomes.

What the researchers tested

The researchers conducted a cross-sectional study at a tertiary care hospital in Central India from May 2023 to May 2024. They compared 312 pregnant participants: normotensive women, women with gestational hypertension, and women with preeclampsia, measuring biomarkers including CPK-MB, LDH, SGOT, high-sensitivity C-reactive protein, glucose, creatinine, troponin I, and NT-proBNP.

What worked and what didn't

There was no significant difference in age or body mass index among the groups. Levels of NT-proBNP, troponin I, CPK-MB, SGOT, and LDH increased stepwise from normotensive pregnancy to gestational hypertension to preeclampsia, and these differences were reported as significant.

What to keep in mind

This was a cross-sectional study, so it measured biomarker levels at one point in time rather than tracking changes over time. The abstract does not describe other limitations.

Key points

  • 312 pregnant participants were grouped into normotensive, gestational hypertension, and preeclampsia categories.
  • NT-proBNP rose from 29 pg/mL in normotensive women to 40 pg/mL in gestational hypertension and 155 pg/mL in preeclampsia.
  • Troponin I, CPK-MB, SGOT, and LDH were significantly higher in the hypertensive disorder groups.
  • Age and body mass index did not differ significantly between groups.
  • The authors conclude the biomarkers may support risk assessment and clinical monitoring.

Disclosure

Research title:
Cardiac biomarkers rise with hypertensive disorders in pregnancy
Authors:
Pawan Kumar Kare, Tripti Saxena, Haresingh Makwane, Pallavi Singh, Shubhishee Joshi
Publication date:
2026-02-25
DOI:
10.7860/jcdr/2026/85062.22912
OpenAlex record:
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AI provenance: This post was generated by gpt-5.4-mini (OpenAI). The original authors did not write or review this post.

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