Focal Interest
Focal Interest

Conjugate

  1. Modified conjugate gradient method showed better numerical performance
  2. Hybrid PRP-MMR method is globally convergent under exact line search
  3. Oxoammonium catalysis enables enantioselective desymmetrization of meso-pyrrolidines
    Oxoammonium-catalyzed desymmetrization of meso-pyrrolidines via enantioselective hydride transfer with over 90% ee, featuring mechanistic insights from isolated intermediates.
  4. Thiolate-mediated cyclization yields 2-quinolones efficiently
    Thiolate-mediated cyclization protocol for synthesis of 2-quinolones and 2-aza-quinolones from aminocinnamic acid derivatives with broad substrate scope and gram-scale scalability.