DNA

Study reveals that antibacterial drugs inhibit different gyrase-mediated catalytic activities at varying concentrations, with DNA topology modulating drug potency beyond DNA cleavage mechanisms.

Study reveals mitotic microhomology-mediated break-induced replication drives chromoanasynthesis, a complex chromosomal rearrangement mechanism in cancer and congenital disorders.

Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.

SFPQ directs histone H3.3 deposition to R-loops in repetitive DNA elements through DAXX recruitment, suppressing replication stress and genome instability while activating innate immune responses.

Donor-derived cell-free DNA quantifies kidney allograft rejection non-invasively across histopathological spectra, with combined scoring optimizing detection of microvascular and antibody-mediated.

Study reveals energy-dependent selective bond cleavage in DNA films exposed to low-energy electrons using XPS analysis, showing preferential damage to N-glycosidic and sugar-phosphate bonds.

Large-scale analysis of DNA quantification metrics and SNP sequencing performance in unidentified human remains shows robust applicability for forensic identification despite moderate predictability.