Focal Interest
Focal Interest

Microbiome

  1. Gut microbiome helps shape Parkinson’s drug interactions
    Drug-microbiome-drug interaction study reveals how COMT inhibitors used with levodopa alter gut bacteria and affect medication metabolism in Parkinson's patients.
  2. Authors propose co-laborative ethics for microbiome research
    Analysis of ethical concerns in human microbiome research, proposing collaborative frameworks to address geographic bias, community exclusion, and underrepresentation of global researchers.
  3. Wild boar and domestic pig gut microbes differ by diet and lifestyle
    Metagenomic analysis reveals distinct faecal microbiome structures in wild versus domesticated pigs, identifying carbohydrate-degrading taxa shaped by diet and lifestyle for probiotic development.
  4. Human and bacterial genetics shape oral microbiome variation
    Study of 12,519 individuals reveals how human genetic variants control oral microbiome composition and link to tooth decay risk through salivary enzyme abundance.
  5. Gut microbiota metabolic reprogramming may drive metabolic disease
    Dysbiosis-induced microbial metabolic reprogramming drives metabolic disease through alterations in lipid, glucose, amino acid, and uric acid metabolism.
  6. Antibiotic use was linked to long-lasting gut microbiome changes
    Population-based study linking 8-year antibiotic prescription data with fecal metagenomes in 14,979 adults to characterize associations between oral antibiotic use and gut microbiome composition.
  7. Ecological network balance index distinguishes healthy and dysbiotic gut states
    Ecological network balance index quantifies positive and negative microbial interactions as a marker of dysbiosis, differentiating health from disease states with mechanistic grounding.
  8. Nasal microbiome linked to modest nasal epigenome variation
    Nasal microbiome composition shows modest but significant associations with epigenomic variation among adolescents, warranting investigation of environmental and developmental factors.
  9. Maternal microbiota affects pregnancy outcomes and infant immune development
    How maternal and infant gut microbiomes shape pregnancy outcomes, immune development, and long-term health during the critical first 1000 days of life.
  10. Gut microbiota shifts and possible markers linked to postoperative enterocolitis
    Longitudinal study identifies distinct gut microbiota alterations in Hirschsprung disease patients, revealing bacterial markers for postoperative enterocolitis risk.
  11. High-resolution spatial transcriptomics maps gut microbiome biogeography
    Spatial transcriptomics method combining enzymatic polyadenylation and RNA sequencing for high-resolution mapping of host-gut microbiome interactions and microbial biogeography.
  12. Maternal HIV linked to altered gut microbes and metabolites
    Longitudinal cohort analysis of gut dysbiosis and metabolomic alterations in mothers with HIV and their infants, identifying microbial and biochemical pathways linked to adverse perinatal outcomes.
  13. Gut microbiome is linked to colorectal cancer development and management
    Review of gut microbiome mechanisms in colorectal cancer carcinogenesis, examining pathogenic bacteria, protective functions, biomarker development, and therapeutic strategies.
  14. Baby-to-baby transmission shapes the infant gut microbiome
    Study reveals how baby-to-baby microbiome transmission in nurseries substantially shapes infant gut health during the first year, complementing maternal microbial inheritance.
  15. FMT with immunotherapy showed activity in NSCLC and melanoma
    Phase 2 trial: donor FMT plus first-line ICI in NSCLC and melanoma showed high ORRs and implicates loss of specific bacterial taxa in association with response.