Focal Interest
Focal Interest

Polymerase

  1. Human Pol-PCNA binds DNA in an unexpected extra site
    Cryo-EM re-evaluation of human DNA polymerase epsilon-PCNA reveals unexpected multi-site DNA binding behavior contradicting prior mechanistic interpretations of mismatch recognition and proofreading.
  2. Pol I transcription is linked to health, disease, and targeted therapy
    Integrated analysis of Pol I structural mechanisms, regulatory pathways, disease associations, and emerging therapeutic strategies targeting this essential eukaryotic transcriptional machinery.
  3. CTF18-RFC structure reveals how it binds PCNA
    Cryo-EM structure of human CTF18–RFC clamp loader bound to PCNA reveals autoinhibited conformation and unique structural features governing leading strand synthesis.