Concept: Processivity
PAF15-PCNA exhaustion limits strand-specific DNA replication control
How a protein complex limits DNA replication when origins fire excessively
Pol I transcription is linked to health, disease, and targeted therapy
How a key enzyme controls ribosome production and drives disease when disrupted
CTF18-RFC structure reveals how it binds PCNA
Molecular structure reveals how a key protein complex loads DNA replication machinery
