Concept: Proliferating cell nuclear antigen
PAF15-PCNA exhaustion limits strand-specific DNA replication control
How a protein complex limits DNA replication when origins fire excessively

AOH1996 remained the most active PCNA inhibitor analog
Novel compounds targeting a key cancer cell protein show promise in reducing cell growth

CTF18-RFC structure reveals how it binds PCNA
Molecular structure reveals how a key protein complex loads DNA replication machinery





