Focal Interest
Focal Interest

Trifluoromethyl

  1. Trifluoromethyl copper complexes were repurposed for saccharide difluoromethylation
    Photo- and acid-mediated repurposing of Grushin's reagent enables efficient difluoromethylation of alcohols, saccharides, and bioactive molecules, generating antifungal leads.
  2. Photocatalysis enables synthesis of trifluoromethyl amidines and imidates
    Photocatalytic metal-free synthesis of α-trifluoromethyl amidines and imidates using isocyanides and trifluoroacetylsilanes, with mechanistic insights from DFT studies.
  3. Metal-free trifluoromethylalkynylation of unsaturated peptides
    Metal-free concurrent trifluoromethyl and alkynyl installation on unsaturated peptides under mild conditions, enabling rapid access to multifunctional peptide scaffolds for medicinal chemistry.