What the study found
The study reports a one-pot three-component synthesis of previously undescribed 3-alkenyl(propargyl)sulfanyl-indeno[1,2-e][1,2,4]triazin-9-ones. It also established the cyclization direction for one representative compound using single-crystal X-ray diffraction.
Why the authors say this matters
The authors present this as the first development of this synthesis route and the first structural determination of the cyclization direction in this reaction system. They also report that some of the products could undergo further heterocyclization.
What the researchers tested
The researchers examined a one-pot three-component reaction involving ninhydrin, thiosemicarbazide, a base, and an alkyl halide. They also tested subsequent heterocyclization of the resulting allyl, methallyl, and butenyl sulfides under halogen treatment.
What worked and what didn't
The synthesis of the new 3-alkenyl(propargyl)sulfanyl-indeno[1,2-e][1,2,4]triazin-9-ones was achieved. The cyclization direction was established by single-crystal X-ray diffraction for 3-allylsulfanylindeno[1,2-e][1,2,4]triazin-9-one, and further heterocyclization was reported for allyl sulfide with bromine, methallyl sulfide with iodine and bromine, and butenyl sulfide with iodine.
What to keep in mind
The abstract does not describe yields, reaction scope beyond the examples named, or experimental limitations. It also does not provide details on conditions or how broadly the heterocyclization results apply.
Key points
- A one-pot three-component synthesis of new 3-alkenyl(propargyl)sulfanyl-indeno[1,2-e][1,2,4]triazin-9-ones was reported.
- Single-crystal X-ray diffraction was used to establish the cyclization direction for 3-allylsulfanylindeno[1,2-e][1,2,4]triazin-9-one.
- Further heterocyclization was achieved for allyl sulfide with bromine.
- Further heterocyclization was achieved for methallyl sulfide with iodine and bromine.
- Further heterocyclization was achieved for butenyl sulfide with iodine.
Disclosure
- Research title:
- New indeno triazinone sulfides and cyclization routes reported
- Authors:
- A. V. Rybakova, Maksim V. Dmitriev, Dmitry S. Kopchuk, Milena E. Sakhautdinova, Anna R. Bezgodova
- Institutions:
- Institute of Organic Synthesis, Moscow Power Engineering Institute, Sirius University of Science and Technology, Solikamsk State Pedagogical Institute, South Ural State University, South Ural State University, South Ural State University, Ural Branch of the Russian Academy of Sciences, Ural Federal University
- Publication date:
- 2026-03-11
- OpenAlex record:
- View
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