Nirmatrelvir-ritonavir did not reduce hospitalization or death

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Research title:

Nirmatrelvir-ritonavir did not reduce hospitalization or death

Authors:

Christopher C. Butler, Andrew Pinto, Victoria Harris, Jane Holmes, Najib M. Rahman, Lucy Cureton, Gail Hayward, Duncan B. Richards, David M. Lowe, Joseph F. Standing, Judith Breuer, Kerenza Hood, May Ee Png, Stavros Petrou, Jienchi Dorward, Mahendra G. Patel, Nicholas P.B. Thomas, Philip Evans, Nigel D. Hart, B Jani, Banafshe Hosseini, Srinivas Murthy, Kerry McBrien, Amanda Condon, Emily G. McDonald, Peter Daley, Michelle Greiver, Bruno R. da Costa, Peter Selby, Peter Jüni, T Lee, Haolun Shi, Michelle A. Detry, Christina Saunders, Mark Fitzgerald, Nicholas Berry, Benjamin R. Saville, Saye Khoo, Jonathan S. Nguyen-Van-Tam, F.D. Richard Hobbs, Ly-Mee Yu, Paul Little

Institutions:

3M (United States), 3M (United States), 3M (United States), 3M (United States), 3M (United States), Berry & Associates (United States), Berry & Associates (United States), Berry & Associates (United States), Berry & Associates (United States), Berry & Associates (United States), Cardiff University, Centre for the AIDS Programme of Research in South Africa, Health Solutions (Sweden), Health Solutions (Sweden), Institute of Infection and Immunity, Institute of Infection and Immunity, McGill University, McGill University, McGill University Health Centre, McGill University Health Centre, Memorial University of Newfoundland, National Institute for Health and Care Excellence, National Institute for Health and Care Excellence, National Institute for Health and Care Research, NIHR Southampton Biomedical Research Centre, North York General Hospital, Nuffield Orthopaedic Centre, Orion Corporation (United Kingdom), Queen's University Belfast, Royal College of General Practitioners, Science Oxford, Simon Fraser University, St Michael's Hospital, St Michael's Hospital, St. Michael's Hospital, University College London, University College London, University College London, University of British Columbia, University of Calgary, University of Cambridge, University of Exeter, University of Glasgow, University of Liverpool, University of Manitoba, University of Nottingham, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Oxford, University of Southampton, University of Toronto, University of Toronto, University of Toronto, University of Toronto, University of Toronto, University of Toronto, Vanderbilt University

Publication date:

2026-04-22

DOI:

10.1056/nejmoa2502457

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