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Non-obstetric SCAD showed mortality and treatment disparities

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Research area:medicine-clinicalcardiovascular

What the study found

Non-obstetric spontaneous coronary artery dissection, or SCAD, was associated with low but clinically significant in-hospital mortality in this U.S. hospital cohort. The study also found differences in treatment and outcomes by sex and race.

Why the authors say this matters

The authors conclude that the findings underscore the need for standardized management strategies and equitable cardiovascular care delivery. The study suggests that persistent sex- and race-based disparities remain important in non-pregnancy-associated SCAD.

What the researchers tested

The researchers conducted a retrospective cohort study using the 2022 National Inpatient Sample, a U.S. database of hospitalizations, and identified adult admissions with a primary diagnosis of SCAD using ICD-10-CM codes. They excluded pregnancy-related admissions, peripartum cardiomyopathy, obstetric complications, and patients under 18 years old, and then used weighted analyses and multivariable logistic regression in STATA 18.0.

What worked and what didn't

A total of 4,563 hospitalizations met the criteria, and 72.6% were female, with a mean age of 52.4 years. In-hospital mortality was 3.2%, women were less likely than men to undergo percutaneous coronary intervention (PCI, a procedure to open a narrowed coronary artery), and Black patients had higher adjusted odds of death than White patients. Cardiogenic shock, chronic kidney disease, and older age were independent predictors of mortality, while PCI was not independently associated with lower in-hospital mortality.

What to keep in mind

This was an observational study based on administrative hospital data, so it describes associations rather than proving causes. The abstract does not describe longer-term outcomes, and the findings apply to hospitalized adults with non-pregnancy-associated SCAD in the 2022 National Inpatient Sample.

Key points

  • The study examined 4,563 U.S. hospitalizations for non-obstetric SCAD.
  • Overall in-hospital mortality was 3.2%.
  • Women underwent PCI less often than men despite similar cardiogenic shock rates.
  • Black patients had higher adjusted odds of mortality than White patients.
  • Cardiogenic shock, chronic kidney disease, and older age predicted mortality.
  • PCI was not independently linked to lower in-hospital mortality.

Disclosure

Research title:
Non-obstetric SCAD showed mortality and treatment disparities
Authors:
Teddy A Teddy, Edidiong Okon-Ben, Spencer Cadet, Abdelwahab Ahmed, Mustafa Marzoung, Allan Bowan
Institutions:
Emerald Coast Science Center, Howard University Hospital, Wayne State University, Wayne State University, Wayne State University, Wayne State University
Publication date:
2026-04-06
DOI:
10.7759/cureus.106537
OpenAlex record:
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AI provenance: This post was generated by gpt-5.4-mini (OpenAI). The original authors did not write or review this post.

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