What the study found
The study found that people with isolated nocturnal hypertension had higher triglyceride–glucose index, triglyceride–glucose–body mass index, atherogenic index of plasma, and C-reactive protein levels than normotensive controls. The authors report that triglyceride–glucose–body mass index and C-reactive protein were independently associated with this blood pressure pattern.
Why the authors say this matters
The study suggests that simple, routinely available clinical markers may help identify isolated nocturnal hypertension, which the authors describe as an underrecognized blood pressure phenotype associated with greater cardiovascular risk despite normal daytime blood pressure. The findings indicate that metabolic and inflammatory markers could be useful in detecting people at increased risk for this condition.
What the researchers tested
The researchers did a retrospective observational study at a single institution. They reviewed 241 people who had 24-hour ambulatory blood pressure monitoring between March 2024 and March 2025, defining isolated nocturnal hypertension as daytime blood pressure below 135/85 mmHg and nighttime blood pressure of at least 120/70 mmHg.
What worked and what didn't
Compared with controls, the isolated nocturnal hypertension group had significantly higher triglyceride–glucose index, triglyceride–glucose–body mass index, atherogenic index of plasma, and C-reactive protein levels. In multivariate logistic regression, triglyceride–glucose–body mass index and C-reactive protein remained independently associated with isolated nocturnal hypertension, and receiver operating characteristic analysis showed moderate discrimination for triglyceride–glucose–body mass index and high discrimination for C-reactive protein.
What to keep in mind
The study was retrospective, observational, and conducted at a single institution, so the abstract does not show that the markers cause isolated nocturnal hypertension. The available summary does not describe other limitations beyond the study design and setting.
Key points
- People with isolated nocturnal hypertension had higher TyG index, TyG-BMI, AIP, and CRP than controls.
- TyG-BMI and CRP were independently associated with isolated nocturnal hypertension.
- CRP showed high discriminatory performance in ROC analysis, while TyG-BMI showed moderate performance.
- The study used 24-hour ambulatory blood pressure monitoring to define isolated nocturnal hypertension.
- The authors describe isolated nocturnal hypertension as an underrecognized phenotype linked to higher cardiovascular risk.
Disclosure
- Research title:
- TyG-BMI and CRP were linked to isolated nocturnal hypertension
- Authors:
- Çağdaş Kaynak
- Institutions:
- Siirt Üniversitesi
- Publication date:
- 2026-03-05
- OpenAlex record:
- View
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