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Rare solitary fibrous tumor found in the floor of the mouth

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Research area:medicine-clinicaloncology

What the study found

The study reports a rare case of solitary fibrous tumor, a rare mesenchymal neoplasm of fibroblastic origin, in the floor of the mouth. The diagnosis was confirmed by histopathological examination and STAT6 immunohistochemistry.

Why the authors say this matters

The authors conclude that this case highlights a rare intraoral presentation of solitary fibrous tumor. They also state that histopathological assessment supported by STAT6 immunohistochemistry is important for accurate diagnosis.

What the researchers tested

The researchers examined a case of a 42-year-old man with a slow-growing, well-circumscribed mass on the left side of the floor of the mouth. They reviewed the gross appearance, microscopic features, and immunohistochemical results.

What worked and what didn't

The mass was described as encapsulated, pink-greyish, and 3.3 cm at its greatest dimension. Histology showed uniform spindle cells in a patternless architecture within variably collagenized stroma, with prominent thin-walled branching vessels, and immunohistochemistry showed diffuse CD34 positivity and strong nuclear STAT6 expression, supporting the diagnosis.

What to keep in mind

This is a single case report, so the findings apply only to this patient. The abstract does not describe treatment, follow-up, or broader clinical outcomes.

Key points

  • A solitary fibrous tumor was found in the floor of the mouth, which the authors describe as particularly rare.
  • The patient was a 42-year-old man with a slow-growing mass on the left side of the floor of the mouth.
  • Microscopy showed uniform spindle cells, a patternless architecture, collagenized stroma, and thin-walled branching vessels.
  • CD34 positivity and strong nuclear STAT6 expression supported the diagnosis.
  • The authors say histopathology plus STAT6 immunohistochemistry is important for accurate diagnosis.

Disclosure

Research title:
Rare solitary fibrous tumor found in the floor of the mouth
Authors:
Meriem Boubekri, Mohamed Amine Essaoudi, Amal Damiri, Hafsa Chahdi, Mohamed Oukabli
Institutions:
Mohammed V University, Mohammed V University, Mohammed V University, Mohammed V University, Mohammed V University
Publication date:
2026-02-24
DOI:
10.1016/j.adoms.2026.100649
OpenAlex record:
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AI provenance: This post was generated by gpt-5.4-mini (OpenAI). The original authors did not write or review this post.

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