What the study found
The study found higher serum cyclophilin A levels in women with preeclampsia than in healthy controls during both the first and third trimesters. It also found that women with early-onset preeclampsia had higher cyclophilin A levels than women with late-onset preeclampsia in both trimesters.
Why the authors say this matters
The authors conclude that the findings suggest a trimester-specific association between cyclophilin A and preeclampsia. They say this warrants further investigation.
What the researchers tested
This was a prospective case-control study of 120 pregnant women without prior medical conditions. Serum samples were collected in the first trimester for all participants and again in the third trimester for women who developed preeclampsia, and cyclophilin A levels were compared between preeclampsia and control groups and between early- and late-onset preeclampsia subgroups.
What worked and what didn't
Cyclophilin A concentrations were markedly elevated in the preeclampsia group compared with healthy controls in both the first and third trimesters. In subgroup analysis, early-onset preeclampsia showed significantly higher cyclophilin A levels than late-onset preeclampsia in both trimesters.
What to keep in mind
The abstract does not describe limitations in detail. It also does not provide information on effect sizes or whether cyclophilin A can be used as a clinical test.
Key points
- Cyclophilin A levels were higher in women with preeclampsia than in healthy controls in both trimesters studied.
- Women who later developed preeclampsia had higher cyclophilin A in the first trimester.
- Women with established preeclampsia had elevated cyclophilin A in the third trimester.
- Early-onset preeclampsia was associated with higher cyclophilin A than late-onset preeclampsia.
- The authors suggest a trimester-specific association between cyclophilin A and preeclampsia.
Disclosure
- Research title:
- Cyclophilin A levels were higher in women with preeclampsia
- Authors:
- Neşet Gümüşburun, Selim Gulucu, Sebahattin ÇELİK, Sercan Serin
- Institutions:
- Balıkesir University, Istanbul Aydın University, Samsun University, Tokat Gaziosmanpaşa Üniversitesi
- Publication date:
- 2026-03-10
- OpenAlex record:
- View
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