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Khamis-Roche estimates agreed well with biological maturity status

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Research area:anthropology-archaeologybiological-physical-anthropology

What the study found

The study found that the Khamis-Roche method, which estimates predicted adult height and percentage of predicted adult height, showed good agreement with bone-age-based estimates of maturity status in this sample. The authors conclude that it may be a valid estimate of biological maturity status in average maturing children and adolescents.

Why the authors say this matters

The study suggests that a simpler estimate based on percentage of predicted adult height can be used to assess biological maturity status relative to skeletal age, with agreement shown in Portuguese children and adolescents. The authors conclude this may be useful for average maturing youths.

What the researchers tested

The researchers studied 371 Portuguese children and adolescents, including 171 girls, aged 11 to 15 years. Bone age was measured with the Tanner-Whitehouse-3 method, and predicted adult height and percentage of predicted adult height were estimated using both the Tanner-Whitehouse-3-based approach and the Khamis-Roche method. They compared the methods using intraclass correlation coefficients, Bland-Altman plots, and two-way analysis of variance.

What worked and what didn't

The average differences between bone-age-based and Khamis-Roche predicted adult height were small and not statistically significant: 0.2 ± 4.2 cm in boys and 0.6 ± 3.1 cm in girls. For percentage of predicted adult height, the differences were also small and not statistically significant: -0.1 ± 2.1% in boys and 0.4 ± 1.8% in girls. The intraclass correlation coefficient for percentage of predicted adult height was above 0.91, and early maturity status was associated with negative differences between bone-age-based and Khamis-Roche predicted adult height.

What to keep in mind

The abstract describes agreement in this sample, but it does not report broader validation beyond Portuguese children and adolescents aged 11 to 15 years. It also notes that early maturity status affected the differences, and the conclusion is limited to average maturing children and adolescents.

Key points

  • Khamis-Roche percentage of predicted adult height showed good agreement with bone-age-based estimates.
  • The study included 371 Portuguese children and adolescents aged 11 to 15 years.
  • Differences between methods were small and not statistically significant for boys and girls.
  • Intraclass correlation for percentage of predicted adult height was higher than 0.91.
  • Early maturity status was linked to negative differences between the two predicted adult height methods.

Disclosure

Research title:
Khamis-Roche estimates agreed well with biological maturity status
Authors:
Isabel Fragoso, João Albuquerque, Júlia Teles, Fabiana Bonito, Luís Miguel Massuça, Fernando Paiva Moura, Carlos Barrigas, Luis Alberto Flores
Institutions:
Autonomous University of Chihuahua, Rede de Química e Tecnologia, Universidade do Porto, Universidade Lusófona, University of Lisbon, University of Lisbon, University of Lisbon, University of Lisbon, University of Lisbon
Publication date:
2026-07-03
DOI:
10.1016/j.jped.2026.101578
OpenAlex record:
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AI provenance: This post was generated by gpt-5.4-mini (OpenAI). The original authors did not write or review this post.

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